Having narrowly lost to Argentina in the opening game, La Tricolor bounced back spectacularly by defeating Uruguay 4-2 at home to finally get their campaign off the ground.
Meanwhile, the Greens languish at the bottom of the standings after losing their opening two games. They were beaten 5-0 by Brazil on the road before Argentina clinched a late victory in Bolivia.
Bolivia vs Ecuador Head-to-Head
In 32 previous official games between these teams, Ecuador has a dominant record with 15 wins compared to Bolivia's seven.
Their last meeting was a year ago in an international friendly, with Ecuador winning 3-0. They were limited to a 2-2 draw on their last visit to the Bolivian capital.
Bolivia Form Guide (all competitions): L-L-W-L-L
Ecuador form guide (all competitions): L-W-L-L-W
Bolivia vs Ecuador Team News
Coach César Farias has announced a fairly young squad for the upcoming matches against Ecuador and Paraguay, with goalkeeping duo Javier Iguaro and Jimmy Roca, as well as defender Luis Demiquel, preparing for their first international matches.
Not available: None
Ecuador has called up Hernán Galíndez, Pedro Perlaza and Adolfo Muñoz for the first time, but veteran midfielder Christian Noboa will miss out as he continues to recover from a torn thigh.
Wounded: Christian Noboa
Not available: None
Bolivia vs Ecuador XI planned
Bolivia (4-4-2): Carlos Lampe; José Carrasco, Saúl Torres, Gabriel Valverde, Jesús Sagredo; Alejandro Chumacero, Diego Wayar, Raúl Castro, Rudy Cardozo; Carlos Saucedo, Marcelo Martins.
Ecuador (4-4-2): Alexander Domínguez; Angelo Preciado, Robert Arboleda, Xavier Arreaga, Pervis Estupinan; Ángel Mena, Carlos Gruezo, Moisés Caicedo, Renato Ibarra; Enner Valencia, Michael Estrada.
Bolivia vs Ecuador Prediction
Bolivia may not be a strong team, but they are not obstacles when playing at home and even the best teams have struggled to win in the extreme altitude of La Paz.
Ecuador is well aware of the challenges, and their last victory in La Paz was in 2009. Captain and star forward Enner Valencia is Tri's biggest threat, and we expect him to score a goal or two in a throbbing draw.
Prediction: Bolivia 2-2 Ecuador